Lens will take a lead to Germany after beating Bayer Leverkusen 2-1 at the Stade Felix-Bollaert.
Olivier Monterrubio's first-half strike and a Daniel Cousin penalty has given the French side the advantage in their Uefa Cup last 16 tie.
Lens opened the scoring through Monterrubio's fine finish past Rene Adler on 17 minutes, and the scoreline stayed that way until five minutes after the break.
Karim Hagui headed the visitors level with a near-post flick from Gonzalo Castro's corner, but the Tunisian soon went from hero to villain.
Hagui was shown a red card by English referee Howard Webb for a foul on Monterrubio in the area and Cousin stepped up to send the goalkeeper the wrong way from the spot.
The ten men of Leverkusen were unable to find an equaliser in the remaining 20 minutes but they will still have hope of making up the deficit at home next week.
Click below for match summary:
Lens 2-1 Bayer Leverkusen