Hibernian's hopes of playing in this season's Uefa Cup were dashed on the away goals rule, as Odense won their Intertoto Cup third round tie after a 2-2 aggregate finish.
The Scottish Premier League club were looking to be one of 11 clubs to claim a place in next Friday's Uefa Cup second qualifying round draw, needing to overcome a 1-0 first leg deficit against their Danish opponents at Easter Road on Saturday.
Following a goalless first half in which Tony Mowbray's side created several chances, it was Odense that struck a telling blow with a valuable away goal shortly after half time.
Tobias Grahn took Morten Fevang's pass before slotting the ball past Hibs goalkeeper Simon Brown to give the Scandinavians a two-goal aggregate lead.
It meant the Edinburgh club needed to score three goals to overturn the tie and Rob Jones gave Hibs a lifeline when he headed home Michael Stewart's wayward strike for 1-1.
That allowed former Newcastle United man Paul Dalglish to score Hibernian's winner 10 minutes from time, as he knocked home Steven Whittaker's pass for 2-1.
Hibs still needed another goal, but Bruce Rioch's Odense held on to secure a place in the Uefa Cup qualifying stages.
Last season's UEFA Champions League semi-finalists Villarreal have crashed out of Europe after a 3-2 aggregate defeat to Maribor of Slovenia.
After losing the first leg 2-1 at El Madrigal, The Yellow Submarines needed an away goal in the second leg to keep their Uefa Cup hopes alive.
With ten minutes left, things looked bleak for Villarreal when Italian defender Alessio Tacchinardi was sent off for a second bookable offence.
Despite being a man short, the visitors took the lead through summer signing Nihat Kahveci (86) before Villarreal were reduced to nine men, as Gonzalo Rodriguez was sent off for serious foul play on 88 minutes.
Two men short, the Spaniards succumbed to a Gorazd Zajc strike (89) before they were further reduced to eight men when Diego Forlan was sent off for serious foul play.
After nearly reaching last season's UEFA Champions League final, Villarreal have missed out on any prospect of European football this coming season.
Twente Enschede are also through to Friday's draw after a 3-1 home win gave the Dutch side a 3-2 aggregate success over Swedish club Kalmar.
All the goals came in the second half, with Twente taking the lead through Kennedy Bakircioglu (48) before Lasse Johansson equalised for Kalmar (66) to hand them a 2-1 aggregate lead.
However, Twente turned the tie on its head with two goals in six minutes from Sharbel Touma (73, 79) to go through.
Ethnikos Achnas of Cyprus are through with a 4-3 aggregate win over Israel's Maccabi Petach-Tikva, despite losing the home second leg 3-2.
Rubel Sarsour (31) and Jefisley Caldeira (44) gave Maccabi a two-goal half-time lead before Ethnikos restored parity with goals from Milan Belic (73) and Christos Poyiatzis (79).
Patrick Suffo (83) gave Maccabi victory on the day, but it was not enough to overcome their Cypriot opponents in the tie.
Turkey's Kayserispor got two goals from Gokhan Unal to defeat Greek club Larissa 2-0 at home - thus taking the tie 2-0 an aggregate.
Goals from Marko Pantelic (25) and Yildiray Basturk (89) gave Hertha Berlin a 2-0 win over FC Moscow in Russia to win 2-0 on aggregate.
French giants Marseille needed the away goals rule to overcome Dnipro after a 2-2 draw in Ukraine.
Following a goalless first leg draw at Stade Velodrome, I'OM got goals from Mamadou Niang (71) and Wilson Oruma (76).
Dnipro quickly replied through Ukraine World Cup squad members Sergei Nazarenko (78) and Andrei Rusol (86), but it was not enough to win the tie.
Marseille's Ligue 1 rivals Auxerre are also through after seeing off Romania's Farul Constanta 4-2 on aggregate, despite losing the second leg away 1-0.
A Todoran Dinu penalty just after half time gave Farul the win, but Auxerre's 4-1 result in the first leg sealed the tie.
Austria's SV Ried earned a 1-1 draw with FC Tiraspol in Moldova to go through 4-2 on aggregate.
Jovan Damjanovic (29) gave Ried the lead before Nicolai Rudac (83) levelled late on for Tiraspol.
The Moldovans finish the second leg with ten men after Andrei Novikov was sent off just before the end.
Swiss giants Grasshoppers defeated Gent 3-2 on aggregate after a 1-1 second leg draw in Belgium.
Brazilian striker Eduardo (64) gave the Zurich club the lead before Irishman Dominic Foley (66) made sure of a consolation draw for Gent.