Toto Nsiala has left Accrington after his contract was terminated by mutual consent, while Cameron Belford has returned to Bury.
Former Everton defender Nsiala joined Stanley on a permanent deal in the summer following a loan spell at the end of last season.
He has made 20 appearances this term in addition to 19 in the previous campaign.
Disciplinary problems dogged the 20-year-old throughout his time at the Crown Ground as he collected a total of 21 yellow cards and one red.
Bury goalkeeper Belford has returned to his parent club following an emergency loan stint with the Reds, during which he made three appearances.