Rotherham won to take over at the head of League Two on Saturday, while Crewe dumped Plymouth to the bottom.
Danny Harrison, Lewis Grabban and Gareth Evans were on target as Rotherham beat Gillingham at the Don Valley Stadium to move to the top of the early table, while the Gills dropped to fourth with the defeat.
Morecambe jumped into second after a 2-0 win at Northampton thanks to Phil Jevons' opener and a penalty from Laurence Wilson.
Previous leaders Crawley Town slipped to third after crashing 3-1 at Cheltenham, with first-half goals from Kaid Mohamed, Marlon Pack and Jeff Goulding sending the Robins into sixth.
Dagenham & Redbridgestay in fifth after being held 1-1 at home to Torquay, with Sam Williams notching for the Daggers and Rene Howe equalising late on for the Gulls.
Southend climbed into the last play-off berth by inflicting a first home defeat on Port Vale in a five-goal thriller at Vale Park.
Mark Phillips, Liam Dickinson and Ryan Leonard were on target for the visitors, with Doug Loft hitting a brace in vain for the Valiants, who dropped to eighth with the defeat.
Oxford United fell to ninth after being held at home by ten men Aldershot, with Luke Guttridge equalising James Constable's opener after Anthony Straker had earlier been sent off for the Shots.
Terry Gornell and Marvin Morgan were on target as Shrewsbury moved into tenth after coming from behind to inflict another defeat Swindon, who drop worryingly to 21st.
At the foot of the table, Plymouth replaced Crewe as the basement side after Shaun Miller gave the Railwaymen their first win of the campaign.
Winless Hereford sit second from bottom after holding Bristol Rovers to a goalless draw.
James Hanson hit a brace as managerless Bradford came from behind to beat Barnet 4-2 and earn their first win of the season.
AFC Wimbledon suffered their first away defeat at Macclesfield, who thumped the Dons 4-0 courtesy of goals from Shaun Brisley, Tony Diagne, Emile Sinclair and substitute Arnaud Mendy.
In the last League Two game, Dean Winnard and Wes Fletcher were on target as Accrington Stanley came from behind to beat Burton Albion at the Crown Ground.