Brentford have been given the go-ahead to leave Griffin Park and move to a new 20,000-seat stadium.
The new ground, which will be situated on Lionel Road - between Kew Bridge station and the M4 - should be ready for the new 2016-17 season.
The scheme, which will include 910 new flats, was approved by Hounslow Council planners, though it is still subject to referral to the Mayor of London and the government.
Cliff Crown, the club's chairman, said: "This is a once in a generation chance to create a vibrant new stadium and adds to the buzz that is going on around Brentford.
"Brentford is on the up as a destination, with new homes, retail, sports and leisure facilities which bring new jobs to the area. Brentford Football Club will be returning close to where it was founded in 1889."
Objections were submitted at the planning committee meeting, primarily about poor transport links and the effect the ground would have on the view from Kew Gardens.
Brentford - who have been playing at 12,763-capacity Griffin Park since 1904 - are losing £5m a year at their current location.