The Yorkshire derby between Sheffield United and Huddersfield takes top billing on a busy night of action in League One.
It is an important evening at both ends of the table with ten games taking place but, with four of the top seven teams not playing, there is an opportunity for Sheffield United to strengthen their position at the summit.
Danny Wilson's Blades are unbeaten in their opening seven games and can put distances between themselves and the chasing pack by beating fifth-placed Huddersfield, who are also yet to taste defeat.
If Sheffield United lose, then Brentford could capitalise on Charlton and Milton Keynes Dons' inactivity by climbing from fourth to first with a home win over mid-table Colchester.
There is a huge clash at the bottom as Leyton Orient, without a win so far this season, tackle a Bournemouth side on a five-match losing streak.
Exeter have also endured a miserable start to the season and will be looking to climb out of the relegation zone by getting the better of ninth-placed Notts County at St James Park.
Scunthorpe were plying their trade in the Championship last term and have struggled to adjust to life back in the third tier, failing to win a match so far ahead of their clash with fellow strugglers Rochdale.
Another game between sides languishing at the wrong end of the table pits Yeovil up against Wycombe at Huish Park.
Walsall lock horns with Oldham as both teams strive to clamber into the top half, while Chesterfield and Bury are also badly in need of points ahead of their meeting at the B2net Stadium.
In mid-table clashes, Tranmere entertain Carlisle at Prenton Park and in-form Sheffield Wednesday travel to Stevenage.