Leaders Milton Keynes Dons face a difficult trip to Carlisle on Saturday, while Sheffield United entertain Bury.
With joint leaders Charlton not in action until Monday against Sheffield Wednesday and high-flying Preston calling off their clash with Wycombe due to international commitments, only two of the top four teams are playing this weekend.
Milton Keynes Dons are currently at the summit on goal difference after four straight wins but Karl Robinson's men must make the long journey to Cumbria to take on a Carlisle side unbeaten in League One since the opening day of the season.
Sheffield United, level on points with MK Dons, could move into first place with a win over Bury, who are presently in mid-table after a solid start to life in England's third tier.
Fifth-placed Tranmere will be hoping to keep the pressure on the leading pack by picking up a victory against lowly Yeovil at Prenton Park.
Highly-fancied Huddersfield have yet to suffer defeat but are outside the play-off zone after starting their campaign with three straight draws, and will now be determined to make it three wins in a row at 16th-placed Oldham.
Hartlepool are another unbeaten side in the division but they have drawn four of their opening five games and will want to turn a promising start to the season into something better when they host Exeter at Victoria Park.
The bottom two sides meet at the B2net Stadium as Chesterfield and Leyton Orient both go in search of their first victories of the campaign.
Two other teams without wins, Rochdale and Scunthorpe, face Stevenage and Colchester respectively on a key day at the wrong end of the table.
Bournemouth will aim to end a run of three consecutive losses when they visit Notts County, while Walsall are at home to seventh-placed Brentford.