Crewe open their League One campaign with a home clash against newly-promoted Rotherham.
Alex, who finished in mid-table last season, will then visit MK Dons before welcoming Ronnie Moore's Tranmere on August 17.
They welcome local rivals Port Vale to Gresty Road on November 23, with the return journey on February 22.
They visit Wolves on Boxing Day, followed by another trip to Colchester three days later, while New Year's Day sees Carlisle visit.
They welcome Wolves on April 12 and visit Shrewsbury on Easter Saturday before heading to Colchester 48 hours later.
Their campaign comes to a close with a home game against Preston on May 3.