Tranmere manager Ronnie Moore admitted Wolves were "streets ahead" of his side as they eased to a 2-0 victory at Molineux.
Rovers arrived in the West Midlands on the back of a 5-1 win at Coventry but were up against it early on when goalkeeper Owain Fon Williams let Leigh Griffiths' 30-yard shot slip through his fingers to gift Wolves the lead.
Dave Edwards headed in the home side's second just before the break and they comfortably held on for all three points.
"To be fair, we have played a super side, haven't we? There is no doubt about that," said Moore. "They were streets ahead of us. Sometimes you have to hold your hands up and say the side are better than you.
"You look at some of the players they have out there, you look at their budget and our budget and that is what you get. So I don't think there is any disgrace in coming here and being beaten."
Moore admitted Fon Williams was devastated by his mistake, adding: "He is in there with his head in his hands.
"But he kept us in the game on Saturday with two great saves. It happens. That is football. He has just got to get on with it."