Barnsley, Brighton, Burnley and Derby will hope to avoid slip-ups against League Two opposition on Tuesday.
The first round of the Carling Cup has thrown up a number of Championship versus fourth tier clashes, providing plenty of potential upsets.
Meanwhile, two of the games scheduled to take place in midweek have been postponed due to the ongoing civil unrest in London.
Brighton made a positive start to life back in the Championship on Saturday and will be hoping to pick up back-to-back victories at their new AMEX stadium home when Gillingham travel to the south coast.
Derby saw off Birmingham at Pride Park over the weekend and will fancy their chances of claiming another home soil success against Shrewsbury.
Barnsley picked up a hard-fought point away at Nottingham Forest in their opening game of the campaign and will take plenty of positives into a meeting with Morecambe.
Burnley will see a first round clash against Burton Albion as an ideal opportunity to pick up their first success of the season.
Coventry were edged out by big-spending Leicester at the weekend and will be looking for a positive response when they go to League One new boys Bury.
Doncaster will be without injured frontman Billy Sharp when they play host to Tranmere, with the visitors possibly sensing a prized scalp could be on the cards in the battle of the Rovers'.
Bournemouth and Dagenham were third tier rivals last season, but the Cherries will now be considered to be the favourites in their cup clash following the Daggers' relegation.
Accrington Stanley gave Newcastle a mighty scare in the Carling Cup last season and will be looking to send Scunthorpe packing this term.
MK Dons are expected to go well in League One this season and it remains to be seen how much importance they play on a date with Cheltenham.
Bristol City's meeting with Swindon has been called off, while Reading's trip to Charlton has also been cancelled on police advice.