A local derby is the pick of the Championship games on Saturday as leaders Queens Park Rangers must wait until Sunday to boost their title hopes.
Eddie Howe is at the helm of Burnley for the first time this weekend, while a couple of other new managers go in search of a first win.
The weekend's action in the division arguably kicks off with the biggest game of the programme as fierce rivals Derby County and Nottingham Forest lock horns at Pride Park in a 1pm kick-off.
The 3pm kick-offs provide second-placed Swansea City with the chance to draw level on points at the top providing they win away at Barnsley.
Swansea's arch enemies Cardiff City currently occupy third place and Dave Jones' side are at home to another play-off contender in the shape of Watford.
Leeds United will be aiming to bounce back from an FA Cup replay defeat by Arsenal by securing a positive result from the long trip to Portsmouth.
Norwich City are the other club presently in the top six and Paul Lambert's side head to Sheffield United, who are yet to win since Micky Adams took charge as manager.
Bottom club Preston North End are yet to pick up three points since Phil Brown was appointed manager and his side head to the North East to tackle Middlesbrough.
Howe finally decided to leave Bournemouth last weekend and his first match as Burnley chief is live on Sky Sports 2 & HD2 away to struggling Scunthorpe United.
Crystal Palace are the other team currently in the relegation zone and new boss Dougie Freedman welcomes Bristol City to Selhurst Park.
Paul Jewell suffered defeat at Millwall in his first game in charge of Ipswich Town and will hope a home date with Doncaster Rovers brings a change of luck.
Leicester City were beaten in a cup thriller at Manchester City in midweek and will now turn their attention to making the play-offs when Millwall visit the Walkers Stadium.
Reading enjoyed an excellent win away to Doncaster last weekend and are at home to a resurgent Hull City this weekend.
The programme concludes on Sunday when leaders QPR aim to pass the 50-point mark for the season with a home game against Coventry City, live on Sky Sports 1 & HD1.