After missing out on Fatih Terim, Siena have wasted no time in finding a new option - and Simone is expected to be in place as soon as the Serie B season finishes this weekend.
Siena president Paolo De Luca had promised the fans of the club an experienced coach after missing out on Terim last week.
Simoni certainly fulfils that requirement having taken Internazionale to a Uefa Cup triumph in 1998.
Meanwhile, Siena could be set to lose several players - with Tore Andre Flo rumoured to be interesting Premiership new boys Crystal Palace and Rodrigo Taddei attracting attention from several top Serie A clubs.