Plymouth will start their new League Two campaign with a trip to Southend on August 3.
The Pilgrims, who narrowly avoided relegation out of the Football League last season, then host Fleetwood before visiting Cheltenham.
On Boxing Day John Sheridan's men travel to Oxford before clashing with AFC Wimbledon in London three days later and hosting Torquay on New Year's Day.
Argyle travel to Torquay on November 26 while the derby games against Exeter are October 5 for the away fixture and March 25 at Home Park.
Plymouth's last fixture is at Portsmouth on May 3, which comes on the back of consecutive home games with AFC Wimbledon and Hartlepool.