League Two's top three, Morecambe, Rotherham and Shrewsbury, are all on the road while Crawley host Paolo Di Canio's Swindon.
Morecambe rose to the top of the table with a thumping 6-0 win over Crawley at the weekend. Jim Bentley's men will seek to keep their noses in front when they travel to Macclesfield.
Rotherham are only second to Morecambe on goal difference and are seeking to keep pace with the Shrimps with a win over Accrington Stanley at the Crown Ground.
Well placed to capitalise on any slip-ups by the top two are Graham Turner's Shrewsbury. They currently sit in third, just two points off the top two and have won their last four games. They face a trip to the Memorial Stadium to play Bristol Rovers.
Di Canio is rarely out of the headlines and has already enjoyed an eventful time at Swindon. After a public falling-out with striker Leon Clarke and a touchline scuffle between a member of his coaching team and Rotherham's Dale Tonge, Crawley boss Steve Evans labelled Town the 'Di Canio circus'.
The Italian responded by claiming he had never heard of Evans and was ready to 'laugh in his face', meaning sparks should fly when the two sides meet at the Broadfield Stadium.
Cheltenham only find themselves above Torquay in fifth courtesy of goals scored. Both sides know a win at Plainmoor could lift them into the top three.
New boys AFC Wimbledon can continue their solid start to life in the Football League by rising into the play-off places with a home win over struggling Northampton.
New Bradford boss Phil Parkinson has begun life at the Bantams with two league draws against Morecambe and Bristol Rovers. He will be seeking a first win in charge away at high-flying Port Vale.
It has been a troubled season so far both on and off the pitch for Plymouth. Peter Reid's men know that even a win away at third-bottom Barnet would not be enough to lift them off the foot of the table.
Hereford have won just once this season and find themselves only four points better off than Argyle. However, a win over Aldershot can see them draw level on points with their opponents in 18th place.
Only goal difference is keeping Gillingham out of the play-offs while their opponents on Tuesday Southend lurk just a point further back. Both sides know a win at Roots Hall could lift them into that elusive top seven.
Elsewhere 11th-placed Dagenham & Redbridge are taking on 14th-placed Oxford at Victoria Road while 10th-placed Burton host 16th-placed Crewe.