Mick McCarthy, Sean Dyche and Dougie Freedman enjoyed immediate impacts in charge of their new clubs, but it was a losing start for Blackburn Rovers boss Henning Berg.
Derby County ensured it was a disappointing day all round for Blackpool, while Middlesbrough's impressive run of form continued to lift Tony Mowbray's men level on points with leaders Cardiff City.
Sheffield Wednesday overcame fellow strugglers Peterborough United, while there were home wins for Hull City and Huddersfield Town, and an away success for Millwall.
DJ Campbell scored after just eight minutes against his former club as Ipswich Town claimed just a second win of the season, in McCarthy's first match as boss, following a 1-0 success at out-of-sorts Birmingham City.
The prolific Charlie Austin was among the goals again as the striker scored in the second half to mark Dyche's first match as Burnley boss with a 2-0 win over Wolves at Turf Moor.
David Ngog scored the winner and was then sent off as Bolton Wanderers came from behind to beat leaders Cardiff 2-1 at the Reebok Stadium in Freedman's first match at the helm.
Glenn Murray scored a goal in each half in front of watching new manager Ian Holloway as Crystal Palace inflicted a first away defeat on Blackburn this season following a 2-0 win at Selhurst Park.
Blackpool endured a miserable afternoon following the departure of Holloway as Theo Robinson scored twice in Derby County's 4-1 victory at Pride Park.
Middlesbrough made it five straight wins in the Championship after coming from behind to romp to a 4-1 triumph away to Charlton Athletic to join Cardiff on 28 points at the summit.
Leicester City dropped out of the automatic promotion places after goals from Almen Abdi and Fernando Forestieri earned Watford a 2-1 home win.
Sone Aluko's 16th minute goal lifted Hull City up a place into fifth spot after a 1-0 win over Barnsley at the KC Stadium.
Sean Scannell's goal just before half-time moved Huddersfield Town to the brink of the play-off places after a 1-0 home success over struggling Bristol City.
Darius Henderson and Chris Wood were among the scorers as Millwall produced one of the performances of the day in winning 4-1 at Nottingham Forest.
Sheffield Wednesday moved out of the relegation zone, and dropped Peterborough United into the bottom three in the process, after goals from Ross Barkley and Miguel Llera clinched a 2-1 win at Hillsborough.