Wolves manager Terry Connor fears midfielder David Davis suffered a broken rib in Sunday's 5-0 loss to leaders Manchester United.
Davis suffered the setback during the first half and he was substituted in the 43rd minute after being replaced by Eggert Jonsson.
The 21-year-old, who has spent time on loan with Chesterfield this season, was being taken to hospital to be assessed.
A spell on the sidelines for Davis if the last thing Wolves need with Jamie O'Hara, Karl Henry and Nenad Milijas are already unavailable.
"Has Davis broke a rib? We believe so. The doctors would like that confirmed, and David is going to hospital, but they believe he's cracked a rib," said Connor.
"Obviously it was enough to cause some damage for him to have to leave the pitch. He'd been playing well and was a vital cog in the way we had set out to play.
"For that opening 20 minutes I thought the midfield had done well against Michael Carrick and Paul Scholes. David was very much a part of that and to lose him was a blow.
"I don't know how long he will be out at this moment but he is very sore at the moment. We will see the extent of the damage over the next couple of days."