Leeds dumped out Everton, Chelsea hit Wolves for six and Aston Villa knocked out Man City in the third round of the Capital One Cup.
Elsewhere, Swansea left it late to beat Crawley and Wigan knocked out West Ham, while Bradford prevailed against Burton.
Leeds caused one of the shocks of the night with a hard-fought 2-1 win over Everton at Elland Road.
Neil Warnock's side stunned their highly-flying Premier League opponents when Aidy White fired them in front after just four minutes with a fine solo effort for his first goal for the club.
Leeds doubled their lead 20 minutes from time with Rodolph Austin diverting Danny Pugh's shot into the net with the slightest of touches.
Everton reduced the arrears nine minutes from time when Sylvain Distin saw his header loop over Leeds keeper Jamie Ashdown and into the net.
Champions Manchester City crashed out to Aston Villa after a 4-2 extra-time defeat at the Etihad Stadium.
City broke the deadlock on 27 minutes when James Milner found Mario Balotelli inside the box and he drilled his shot low into the net.
Villa were gifted a route back into the game just before the hour mark when former Villa man Gareth Barry deflected Andreas Weimann's cross into his own net much to the delight of the travelling fans.
Parity proved short-lived as City restored their lead on 64 minutes when Aleksandar Kolarov curled a superb free-kick over the wall and past former City keeper Shay Given.
Villa fought back and sent the game into extra-time when Gabriel Agbonlahor powered into the box and fired home an equaliser pas Costel Pantilimon on 70 minutes.
The visitors took the lead for the first time in the contest six minutes into extra-time when Pantilimon failed to deal with Agbonlahor's shot and Charles N'Zogbia was on hand to snaffle up the rebound.
Villa put the game beyond City when the impressive Agbonlahor made it 4-2 seven minutes from the end of extra-time with a deflected effort which looped over Pantilimon.
Chelsea cruised into the fourth round with a thumping 6-0 win over Championship side Wolves at Stamford Bridge.
Gary Cahill set Chelsea on their way with the opener after just four minutes and Ryan Bertrand doubled the lead four minutes later.
Juan Mata made it 3-0 on 17 minutes with his first goal of the season and Oriol Romeu celebrated his birthday with the fourth from the penalty spot on 53 minutes after Victor Moses was brought down by Dorus De Vries.
Fernando Torres got in on the act just before the hour mark when he headed home Mata's corner for his first goal in five games.
Victor Moses completed the rout for Chelsea with his first goal for the club on 71 minutes.
Ten-man Sunderland avoided an upset with a 2-0 win at League One outfit MK Dons.
Sunderland were reduced to 10 men just past the half hour when Lee Cattermole was sent off for violent conduct for a foul on Adam Chicksen.
The Premier League side made light of their numerical disadvantage on 54 minutes when Craig Gardner scored with a superb free-kick from 25 yards out.
James McClean put the game beyond MK Dons with Sunderland's second goal eight minutes from time.
Garry Monk's last-gasp goal earned Swansea 3-2 win over Crawley as Michael Laudrup's men survived a major scare.
Michu made the breakthrough for Swansea on 27 minutes with a superb curling effort, but Crawley drew level right on the stroke of half-time with Josh Simpson's deflected effort.
Hope Akpan gave the League One side the lead on 62 minutes, but Danny Graham came off the bench to draw Swansea level 16 minutes from time.
It looked like the tie was heading to extra-time until Monk popped up in the closing seconds to send Swansea through.
Wigan came from behind to dump out fellow Premier League side West Ham after a 4-1 win at Upton Park.
Modibo Maiga gave West Ham the lead after just seven minutes, but Mauro Boselli drew Wigan level seven minutes later.
Ivan Ramis fired Wigan in front on 38 minutes with a long-range effort and Boselli gave Wigan a two-goal cushion with his second of the game four minutes before the break.
Jordi Gomez wrapped up the game with a fourth for Wigan from the penalty spot six minutes from time after James McArthur was brought down by Stephen Henderson.
Swindon, who knocked out Stoke in the previous round, secured another cup upset with a 3-1 victory over Championship Burnley at the County Ground.
Paul Benson gave Paolo Di Canio's men the lead on 19 minutes and Andy Williams doubled the advantage three minutes before the break.
Former Swindon man Charlie Austin pulled a goal back for Burnley on 74 minutes, but Troy Archibald-Henville made the game safe for Swindon with their third seven minutes from time.
Bradford came from two goals down to knock out fellow League Two side Burton 3-2 after extra-time.
Burton looked to be heading to a comfortable win when they raced into a 2-0 lead thanks to goals from Billy Kee (18) and Aaron Webster (29).
However, two late goals from Nahki Wells (83, 90) sent the game into extra-time and five minutes from the end of the extra 30 minutes former Liverpool defender Stephen Darby popped up with the winner.
Jay Rodriguez scored his first two goals for Southampton to help them to a 2-0 win over Sheffield Wednesday at St Mary's.
The summer signing from Burnley netted his first of the game on the half-hour mark and he doubled the lead from the penalty spot 12 minutes from time.
Middlesbrough proved too strong for Preston running out 3-1 winners at Deepdale.
Richie Smallwood restored Middlesbrough's two-goal cushion just past the hour mark to send Tony Mowbray's side into the fourth round.