Burnley can seal their promotion to the Premier League on Good Friday.
The Clarets, who spent the 2009/10 season in the top flight before being relegated back to the Championship, will join already-promoted Leicester if they win at Blackpool and third-placed Derby fail to beat Doncaster.
A victory for the Rams at the Keepmoat Stadium would see them seal a play-off spot.
In League One, Wolves have already won promotion and could effectively seal the title if they beat Rotherham and Brentford lose at home to Preston.
A defeat for the Bees and a win for Wolves would see Brentford nine points behind Wolves, but with Wolves having a far superior goal difference Brentford would have to win their remaining games, hope Wolves lose all theirs and overturn a 22-goal deficit.
However, Brentford will join them in the Championship next season if they win, Leyton Orient lose and Rotherham fail to win at Molineux.
There is only one play-off spot still up for grabs and Peterborough will claim it on Friday night if they win at Bradford, Swindon lose and both Milton Keynes Dons and Sheffield United fail to get anything but three points.
In League Two, a win for Scunthorpe on Friday will leave them on the brink of promotion to League One.
A defeat for Fleetwood on the same day and a loss by Burton on Saturday would confirm the Iron's elevation.
Fleetwood have their own motivation when they face Cheltenham on Friday, though, as a win would see them seal the last remaining available play-off spot.
Torquay could face an agonising wait to see if they have survived relegation for another weekend.
Defeat at home against Dagenham & Redbridge leaves them vulnerable to the drop if Exeter avoid defeat and Wycombe and Northampton do not draw with each other on Friday, and then Bristol Rovers win on Saturday.
Luton have already sealed the Conference Premier title, while Cambridge have claimed one of the four available play-off spots.
Mathematically, the teams from third to 12th remain in contention for the top six but wins for Halifax and Grimsby - currently third and fourth respectively - will see them seal a play-off spot if results go their way this weekend.
There is only match in Scotland on Friday with Inverness hosting Aberdeen.
The Dons can strengthen their grip on second place with a victory at Caledonian Stadium, with third-placed Motherwell - who are currently three points behind them - facing champions Celtic on Saturday.