Blackburn's match against Brighton was the first Championship game to be called off as wet weather disrupted Saturday's sporting programme.
The heavy rainfall, which has affected numerous fixtures, forced the cancellation at Ewood Park due to a waterlogged pitch.
A post on Blackburn's official Twitter feed read: "Today's match against Brighton has been called off due to a waterlogged pitch. A new date will be arranged in due course."
A further statement on the Blackburn website said: "Referee Robert Madley made a pitch inspection at 12.15pm and with player safety paramount, deemed the pitch unplayable due to the heavy rain experienced in Lancashire over the last few days."
The lower league fixture list was reduced by the wet conditions, with the League One meetings between Doncaster and MK Dons and Crewe and Bournemouth the latest games to fall by the wayside.
Crewe had held a second pitch inspection at 12.15pm, an hour after the surface was first assessed, but were left with no option but to call the match off, while coaches carrying the Cherries fans had already been advised to stop on their way north before a decision was made.
That left just five games set to take place in the third tier, at Coventry, Crawley, Notts County, Walsall and Yeovil.
In League Two only the games at Northampton and Accrington were set to go ahead, although the former were set to hold another pitch inspection before making a final decision.