Paul Mariner believes strikers Alan Gow and Steve MacLean have played their last games for Plymouth.
MacLean is currently out on loan at Scottish Premier League outfit Aberdeen, while Gow is at Hibernian, but both have said they do not want to return to Home Park.
While the pair are under contract to Plymouth next season, it seems they will be allowed to leave in the summer as the relegated club slash their wage bill as they prepare for life in League One.
Mariner told the Plymouth Herald: "Steve MacLean has come out publicly and said he doesn't want to play for Plymouth Argyle. So I think it's very difficult for him to come back.
"Our supporters are extremely passionate about the club, and they want people to be fighting tooth and nail for the cause.
"If it was me, I wouldn't have made any statements like that, but that's me.
"I think they have burned their bridges. It's going to be difficult for them to walk into the dressing room, and they have got to try to rebuild a rapport with the supporters, and that's always difficult.
"It's a case of watch this space. We will have to wait and see."
The club's versatile left-sided player Jim Paterson has another season remaining on his contract but is also likely to be allowed to leave this summer.
The 30-year-old was out on loan at Aberdeen but has now returned to Home Park for treatment after suffering an Achilles tendon injury in March.
Mariner added: "I haven't spoken to Jim, but I know he has been working very hard to try to get right."
Meanwhile, Mariner is interested in signing Nigerian striker Jeremiah Ani, who has impressed while on trial with the club.
The 25-year-old has been without a club since leaving Finnish outfit Rovaniemen Palloseura late last year but did well for the Pilgrims' reserves in their 1-0 loss to Reading on Monday.
He was subsequently invited to spend the rest of the week training with the Pilgrims' first-team squad and has again impressed.
Mariner said: "We have brought him back just to have a look.
"He has trained with the lads this week and it's always very difficult for people to show what they can do in a completely foreign environment. But he has got the attributes to be a player."