Plymouth skipper Karl Duguid looks to be out of action for the rest of the year with a calf injury.
The 30-year-old was absent from Tuesday's goalless draw at Southampton after limping off in Saturday's win over Cardiff.
Pilgrims boss Paul Sturrock has confirmed an expected six-week stint on the sidelines for his skipper which could force the club into the loan market before Thursday's deadline.
"Duguid's out between four and six weeks," Sturrock told the club's official website.
"It will be a blow because he is the captain of the team and has shown an amazing standard of performance for not playing very often in the centre of midfield.
"We are going to miss him."
Sturrock has the option of bringing Yoann Folly or Luke Summerfield in to help bolster his current squad.
Asked if he would consider bringing in reinforcements on loan, the Pilgrims boss said: "I'll have to wait to talk to the chairman and the board about it.
"We can't leave ourselves short over the next six weeks, especially when the transfer window closes on Thursday.
"We'll wait and see. We're over budget, pure and simple, so I'll have to get on my prayer mat and see how that works on the chairman.
"I'd like to put two or three players out on loan to balance the books, but it's going to be difficult in a two-day span."