Championship leaders Blackburn Rovers will hope to set the tone for the weekend as several clubs go in search of their first points away from home.
Peterborough United will be determined to finally get up and running at the seventh attempt as the second-tier programme is spread over four days.
The action gets under way on Friday night when Blackburn's 100 per cent home record is on the line again when Middlesbrough, without a point on their travels, head to Ewood Park.
With Blackpool not in action until Monday, Brighton & Hove Albion could jump up to second as Gus Poyet's side chase a second away win of the week at Millwall.
Darren Ferguson has vowed to stay as Peterborough manager after starting the season with six straight defeats and he welcomes one of his former clubs Wolves to London Road.
Birmingham City picked up a second home win of the season in midweek and Lee Clark's men will be confident of another when Barnsley, who have lost all three away games, visit St Andrew's.
Bolton were beaten at Birmingham on Tuesday and Owen Coyle has been fending off talk his job could be in jeopardy before taking his relegated side to Sheffield Wednesday in the hope of a first away point.
Burnley are another team to have lost all three away games so far and they go to Derby County, who have scored 10 goals in three outings at Pride Park in the league.
Nottingham Forest have drawn all three of their matches on the road this season and will face a Leeds United outfit striving for consistency at Elland Road.
Ipswich Town and Charlton Athletic are both in the bottom three at this early stage of the campaign and Paul Jewell's side are one of only two teams not to win at home this season.
Cardiff City claimed a first away win at Millwall on Tuesday and return to the capital to take on Crystal Palace at Selhurst Park.
Watford are still adjusting to a mammoth change in personnel following their summer takeover and appointment of Gianfranco Zola as manager, and Bristol City are the visitors to Vicarage Road on Saturday.
On Sunday, Nigel Pearson comes up against his former club when Leicester City's 100 per cent home record will be tested by Hull City.