Southampton have the opportunity to move clear at the top of the Championship table on Tuesday night, while three teams will be hoping to get their first points on the board.
Of the five sides to have won their opening two games of the season, only Southampton are in action on Tuesday night as Nigel Adkins takes his men to Portman Road to face an Ipswich outfit that has lost twice at home already in all competitions.
Reading produced an impressive display to beat highly-fancied Leicester at the weekend and could move second with an away victory over Portsmouth, who have so far collected just one point.
Unbeaten Middlesbrough will be looking to continue their fine start to the campaign when they travel to Oakwell to lock horns with Barnsley, one of three teams yet to score in the Championship.
Nottingham Forest have not managed to find the target either but Steve McClaren has added Ishmael Miller to his squad since Saturday's 2-0 defeat to Millwall and the striker could be in line for an immediate debut against a Doncaster side that has suffered back-to-back league defeats.
Leeds find themselves in the bottom three after a couple of early losses and will want to get back on track in the Yorkshire derby with Hull City at Elland Road.
West Ham bounced back from the disappointment of losing at home to Cardiff to overcome Doncaster last time out and another away victory against Watford would push them into a strong position.
Coventry, who have suffered 1-0 reversals in each of their opening games, journey to Crystal Palace in the night's final game.