Alan Pardew was left to lament injury to Anton Ferdinand following West Ham's defeat at Manchester City.
The accomplished stopper limped out of the 2-0 loss just past the 20 minute mark with a hamstring injury.
Ferdinand is consequently a major doubt for West Ham's Uefa Cup game against Palermo on Thursday, with Pardew disappointed one of his key men will now likely be absent.
"We'd come and settled the crowd, got a foothold in the game and then we had to take him off," he told Sky Sports News.
"It really did disrupt us, I think it probably contributed to our defeat today. He's pulled his hamstring.
"We'll have to see how bad the tear is, if there is a tear.
"He's a big player for us, so it's a real shame."
Pardew admits that neither side particularly impressed at Eastlands, of the opinion that it was two nervous teams, looking for confidence, in what was a poor game overall.
"It was a nervy game, a battle in the midfield with passes going astray from both sides," he concluded.
"We're searching for that little lift you can get. Unfortunately, we're not getting the breaks."