Fulham have confirmed that Franck Queudrue is set for at least a month on the sidelines.
The French stopper suffered a badly gashed ankle during Saturday's 1-0 defeat to Reading.
"It is a bad one for Franck," admitted Fulham boss Chris Coleman.
"We were disappointed with the challenge even though I don't think the guy meant to do it, but he got it wrong.
"We are looking at three weeks to a month out for Franck because the gash in his ankle is so nasty.
"We've got nobody else who can play centre-half and it looked at one time as though we might have to play big Dave Beasant (the club's goalkeeping coach and former Wimbledon, Chelsea and Newcastle goalkeeper) at centre-half on Wednesday."
With Ian Pearce facing a suspension ahead of Wednesday's clash with Arsenal - Philippe Christanval could be in line for a rare start.
The French international has not played since August due to a knee problem but is now back in full training and could be thrown in at the deep end against The Gunners.