Manchester City striker Sergio Aguero has been ruled out of Wednesday's crunch clash with Aston Villa because of a groin strain.
Aguero suffered the injury in the first half of last week's 3-2 victory at Everton, and came off shortly after scoring and making it 1-1.
The Argentina star will definitely miss Wednesday's match with Villa, and is a doubt for City's final match of the season against West Ham.
Following Liverpool's dramatic collapse at Crystal Palace on Monday night, where the Reds let a 3-0 lead slip and drew 3-3, City need four points from their final two Premier League matches to win the title.
City boss Manuel Pellegrini said: "Sergio couldn't recover 100 per cent from his groin problem, so he is not in the squad list.
"Maybe he can have some chances (for the West Ham match), we will see the way he improves during the week.
"It was not 100 per cent sure if he was completely fit for Wednesday, that is why I didn't want to have a risk with him, but we will see during the week if he can play on Sunday."
Watch Manchester City take on Aston Villa live on Sky Sports 1, with coverage from 7pm on Wednesday evening.