The Football Association has rejected Joey Barton and Paul Konchesky's appeals for wrongful dismissal following their respective red cards on 23rd December.
Manchester City midfielder Barton will now serve a three-match ban with immediate effect, whilst West Ham full-back Konchesky is suspended for a single game.
Barton was given his marching orders in the final minutes of City's 2-0 defeat to Bolton as he jumped at Trotters defender Abdoulaye Diagne-Faye near the touchline.
Stuart Pearce outlined his plan to appeal immediately after the game, but the City boss will now be deprived of one of his key men at a crucial period in the season.
Konchesky saw red on the same day for a perceived professional foul on Fulham's Wayne Routledge, and Hammers boss Alan Curbishley was hopeful following the 0-0 draw that referee Chris Foy would overturn the decision.
Coincidentally, both players will now be suspended for Saturday's game between the two sides at Upton Park, whilst Barton will also miss City's Premiership game with Everton on New Year's Day and the FA Cup tie at Sheffield Wednesday.
The FA has also confirmed that Preston's Danny Dichio has had his claim for unfair dismissal rejected following a red card against West Brom on Boxing Day, meaning the striker will miss three games.
Southend defender Efe Sodje withdrew his own appeal before the hearing on Thursday and will now also serve a three-match ban.