Stephen Carr and Stephen Ireland have withdrawn from the Republic of Ireland squad for this week's Euro 2008 qualifier with San Marino.
Newcastle United defender Carr has been forced to pull out with an ankle injury he picked up in Saturday's goalless draw with Manchester City.
Midfield star Ireland is struggling with a virus and will not travel to Dublin.
Ireland boss Steve Staunton has decided not to call up any replacements to provide cover for the absent duo.
Leeds United midfielder Jonathan Douglas and Everton's Lee Carsley are also slight doubts for the clash with minnows San Marino on Wednesday, which you can see live on Sky Sports 1.