Newcastle boss Glenn Roeder has confirmed keeper Shay Given damaged a groin against Arsenal, but Kieron Dyer was withdrawn as a precaution.
The Irish star limped out of the 0-0 draw shortly after making a save to deny Emanuel Adebayor.
Given has had an injury-ravaged season, having suffered a perforated bowel against West Ham and Roeder feels the keeper's recent troubles are related to the problem he picked up against The Hammers.
"He has injured we think his right groin now," Roeder told Sky Sports News. "We think it all relates back to the operation he had to have after getting injured at West Ham.
"He had a perforated bowel. The two groin injuries he has had this year, I think all lead back to the operation he had after West Ham.
"Shay Given is never injured, but he has now been injured three times this season."
Roeder is not ruling out Given playing again this term.
"He will probably struggle for the weekend but we don't believe his season is over at all," he added.
Kieron Dyer was forced off with a slight hamstring strain, but Roeder claims his withdrawal was a precaution and insisted it was not related to the problems which have blighted the midfielder's career.
"It was my decision to take him off to protect him and keep him fit for the rest of the season, not just Portsmouth," added Roeder. "We made a substitution early rather than wait for it to ping and then take him off."