Blackburn Rovers boss Steve Kean says injuries to key players forced the changes that cost his side in their 3-0 away defeat to Swansea City.
Rovers offered little in response to Swansea's free-flowing football with on-loan Gylfi Sigurdsson curling in the opener on 37 minutes, Nathan Dyer netting six minutes later and Scott Dann's own goal completing the scoring after 63 minutes.
Kean revealed after the Liberty Stadium defeat that he was forced to take off Grant Hanley, top scorer Yakubu and Junior Hoilett due to injury.
"Grant Hanley rolled his ankle, Yakubu was feeling his patella tendon on his knee, Junior Hoilett was feeling his hamstring, so I had to try and re-shuffle which was difficult," Kean told Sky Sports.
"I think Grant's is serious as there was no way he could come back on and there's quite heavy swelling in his ankle.
"Yakubu has had a problem before, the medical team said we have to get him off in case it totally goes and Junior's is a precaution.
"Hopefully Junior and Yakubu will have an outside chance but I think Grant will struggle to come back."
Asked if he is confident Blackburn can stay up with only four games remaining, Kean was positive.
He replied: "We're confident because it's really clear and apparent what we need to do now. We're going to have to win our next two games and get a draw from somewhere.
"We have to patch ourselves up and make sure we get a team on the pitch that is really going to work hard and I'm sure we can do it.
"I think we need a minim of seven points and so that's what we'll be aiming to do."