Tottenham boss Harry Redknapp has confirmed Michael Dawson is very unlikely to play again this season after being stretchered off in the FA Cup win over Stevenage.
The England international was injured in the opening stages of Wednesday night's 3-1 victory at White Hart Lane when he landed awkwardly following an aerial challenge with Chris Beardsley.
Dawson was in agony as crumpled to the turf and the 28-year-old was taken to hospital after being carried off amid reports he had suffered ruptured ankle ligaments and also damaged his knee.
The former Nottingham Forest centre-back is now in danger of missing the remainder of the season for Redknapp's side, with his Euro 2012 hopes also in the balance.
Redknapp told ESPN: "Unfortunately we picked up a couple of nasty injuries tonight. Michael Dawson looks like he has got a really bad injury, which is a massive blow for Michael and everybody.
"Michael has gone to hospital. It was his ankle and his knee. He has a pretty bad injury there. It's long-term, for sure.
"Looking at his injury it would be a miracle to think he is not (out for the season). You never know but it didn't look good at all. It is a big blow for us and for Michael.
"It's a big loss, he is a big professional. You want him around your team, that's for sure."
Aaron Lennon was also forced out of the contest prior to the interval with a recurrence of his hamstring problem, an injury which Redknapp is now causing concern.
The Spurs boss said: "He tweaked his hamstring a little bit again. Every time he plays he seems to do his hamstring.
"We have just got to look at that and see what we can do to strengthen his hamstrings."
On the game itself, Redknapp added: "It was a difficult game, just what I expected. People said 'you'll smash them, beat them five or six'. Not a chance.
"It was a difficult game, but we came through okay in the end.
"The lads showed good character to come back from 1-0 down."
Redknapp also had words of praise for Defoe as he said: "He looked sharp tonight and took his goals well so that's good."