Juande Ramos insists the Uefa Cup is as important as Tottenham's battle to drag themselves out of danger in the Barclays Premier League.
Spurs start their Group D campaign away to Udinese on Thursday before returning to league action at home to Bolton on Sunday.
With league games against Arsenal and Liverpool during the following week, that is seen as a must-win game for Spurs, although Ramos puts the same importance on European success.
"Both competitions are important," he said.
"The most important is the Uefa Cup because this is our next game. On Friday, the most important is the Premier League."
Ledley King's persistent knee problem means he struggles to play twice in a week while fellow defender Vedran Corluka is cup-tied having already played for Manchester City in the Uefa Cup.
"The problem with the Uefa Cup is that it is not possible to play Corluka and Ledley King (regularly)," Ramos added.
"We only have Jonathan Woodgate and Michael Dawson as alternatives and we need to think in both competitions.
"Corluka can only play in the Premier League so we have to play him in that competition.
"On Sunday, if it is possible to play Ledley we will, but he needs 10 days to recover. We use the players in the best condition. It is impossible to play the same team, it depends on injuries and suspensions."
Alan Hutton is available to make his first European appearance for Spurs as the former Rangers full-back was cup-tied for last season's UEFA Cup.
The Scotland international recovered from a foot injury to make his first appearance of the season in Sunday's 2-1 defeat at Stoke, when he was booked for a late challenge on goalkeeper Thomas Sorensen, who has claimed he was a millimetre from losing his sight.
"It's harsh," said Hutton. "I said I was sorry and I totally mean that. I'd like to say sorry again. Hopefully he'll be back as soon as possible.
"I've been in that position before myself and I would never go out and try to harm anyone. It was one of those things.
"I've received bad tackles, it's a contact sport, I don't say anything about it."