Portsmouth's Glen Johnson and Jamie Ashdown have both had their FA Cup winners' medals stolen.
In separate incidents, the two have both seen their medals disappear after Saturday's win over Cardiff City at Wembley.
The club's chief executive Peter Storrie has now called for the medals to be returned.
"They both appear to have gone missing in different circumstances," Storrie told Sky Sports News.
"The hotel has looked after us fantastically over the weekend, but it appears someone has gone in and taken something out of Jamie's pocket and with Glen it looks to have come out of a wash-bag.
"The hotel are looking at all the CCTV and obviously the police are aware.
"I would appeal - if you had taken them, whatever you do just send them back and no action will be taken as long as the players get them back."