Championship leaders Blackpool travel to Barnsley on Saturday, while Peterborough take on Burnley in a bottom-of-the-table clash.
But ahead of the Saturday games, Brighton or Sheffield Wednesday could go to the top of the table when the sides clash at the Amex Stadium on Friday night.
Gus Poyet's Seagulls sit fourth in the early table with seven points from their opening four games, the same tally as the sixth-placed Owls and a win would take either top.
In Friday's other game, last season's League One champions Charlton take on local rivals Crystal Palace in a clash being shown live on Sky Sports 1HD at 7.45pm.
The Eagles lost their first three games but bounced back to beat the Owls last time, while the Addicks will be looking to earn their second win of the campaign.
In Saturday's action, current leaders Blackpool travel to Barnsley looking to bounce back from a 1-0 loss at Leicester last time, while the Tykes will be aiming to maintain their 100 per cent home record.
Second-placed Blackburn put their unbeaten away record on the line at Bristol City, who have won both of their games at home this term.
Unbeaten Nottingham Forest sit third in the early table and next up for Sean O'Driscoll's side is the visit of lowly Birmingham, who are yet to earn a point away from home.
Fifth-placed Hull City will be looking to make it three wins on the bounce at home against Millwall, who have started solidly with two victories so far.
Cardiff and Leeds sit just outside the play-off berths with seven points apiece and it is sure to prove a hotly-contested affair in Wales.
The Bluebirds would seem to be slight favourites having won both their home games so far this term, but Leeds boss Neil Warnock will demand a full effort from the Whites.
Middlesbrough put their 100 per cent home record on the line against Ipswich at The Riverside, while Huddersfield aim to stay unbeaten at home to Derby, with both sides locked on five points from their opening four games.
Down at the bottom, Darren Ferguson's Peterborough travel to third-from-bottom Burnley looking to pick up their first points of the campaign.
Bolton hover just two places - and one point - above the early drop zone and next up for Owen Coyle's side is the visit of Watford, who sit in mid-table after two wins from their opening four games.
In Sunday's game, Wolves host Leicester in a clash of sides with Premier League aspirations, which is being shown live on Sky Sports 1HD at 1.15pm.