Blackpool will look to stretch their 100 per cent start to the season in front of the Sky Sports cameras, while four other clubs defend unbeaten records.
At the other end of the Championship spectrum, Crystal Palace and Peterborough will be hoping to open their accounts after stumbling out of the blocks.
Blackpool are the only side to have taken nine points from three games so far and will be looking to make it 12 from 12 when they travel to Leicester in a game which can be seen live on Sky Sports 2 HD.
Sheffield Wednesday have impressed upon their return to the second tier and will be full of confidence heading into a trip to pointless Crystal Palace.
Blackburn Rovers have £8million frontman Jordan Rhodes ready to unleash on Leeds, but will be aware that the Whites are a formidable proposition at Elland Road.
Nottingham Forest and Charlton are yet to taste defeat in the league this season, and they will go head-to-head at the City Ground on Saturday.
Bristol City were unfancied heading into the campaign, but back-to-back victories suggest they could be about to pile more misery on out-of-sorts Barnsley.
Watford have enjoyed an impressive opening and will be hoping to ensure that Derby end the weekend still looking for their first win.
Middlesbrough occupy a standing inside the top six at present and go in search of a third straight victory at Millwall.
Huddersfield begin life without their most potent goal threat on the road at Ipswich, who were hit for six by Blackpool last time out.
Few people would have expected Birmingham to only have one point to show for their efforts three games into the season and they need to start turning things around in a home date with a Peterborough side yet to get off the mark.
Hull City and Bolton are locked together in mid-table, sat on four points, but will become upwardly mobile if they can claim victory in a clash at the KC Stadium.
Brighton make the long trip north to Burnley looking to place themselves among the early frontrunners.
On Sunday, Cardiff and Wolves will attempt to establish forward momentum when they lock horns in South Wales.