Arsene Wenger has insisted that Chelsea have a better chance of protecting their lead at Camp Nou than Arsenal did 12 months ago.
The Blues head to Spain with a hard-earned 1-0 advantage from the first leg at Stamford Bridge last week, when Barcelona produced a lacklustre display in west London.
Chelsea caretaker boss Roberto Di Matteo made sweeping changes for Saturday's Premier League clash at Arsenal, where they battled to a goalless draw.
Pep Guardiola could not afford the same luxury as Barca were beaten 2-1 by Real Madrid to effectively end their chances of winning the Primera Liga.
Wenger feels recent results have shown that Barca are not invincible and says Chelsea should approach their latest game in a positive frame of mind.
Arsenal came close to knocking out Barca last season in the round of 16 as they won the first leg at Emirates Stadium 2-1, before being eliminated 4-3 on aggregate.
While Barca carved out several chances to win by a more convincing margin, the Gunners would have gone through on away goals if Nicklas Bendtner had taken a glorious late chance in the second leg.
Wenger said: "It is far from impossible to qualify there because Chelsea go even in a better position than us, they won 1-0 - it is a fantastic result 1-0.
"Also, the Barcelona we have seen the other night it is not the Barcelona of last year.
"As well, Chelsea could rest eight players against us. Barcelona could not afford to rest anybody on Saturday night."
Chelsea drew some criticism for perceived negative tactics in their victory.
While Wenger understands sometimes it is not always possible to be on the offensive, the Gunners boss feels Chelsea could effectively kill the tie by showing some ambition.
"You wonder as well is it not worth to try to score a goal? That would mentally be a massive blow to them because I have seen last year when we scored last season, yes it was a lucky goal, but I could see suddenly they became very nervous," he added.