Man Utd and Man City maintained their 100 per cent records, whilst Chelsea, Arsenal, Tottenham and Stoke all claimed wins.
But Liverpool saw their unbeaten start to the season disappear as they went down 1-0 at Stoke City.
And Aston Villa twice came from behind to claim a 2-2 draw at Everton.
Wayne Rooney netted another hat-trick to inspire Manchester United to a 5-0 thumping of Bolton at the Reebok Stadium.
England ace Rooney followed up his hat-trick in the 8-2 mauling of Arsenal with another superb treble to send United to the top of the table to become only the fourth player in Premier League history to score consecutive hat-tricks
Javier Hernandez marked his first start of the season with a brace to complete another comprehensive win for Sir Alex Ferguson's in-form troops to send them back to the top of the table.
City crushed Wigan at the Etihad Stadium as Sergio Aguero scored a superb hat-trick.
Aguero was paired up front with fellow countryman Carlos Tevez for the first time and they ran riot.
Aguero's first came after just 13-minutes. Tevez's run down the left found David Silva and he was given all the time in the world to find Aguero, who fired into the bottom corner.
Tevez then wasted a gilt-edged chance to double their lead as his weak penalty was tipped wide by Al-Habsi.
But City and Aguero took control in the second-half and their second arrived with a wonderful free-flowing move. Substitute Samir Nasri found Silva, he then played in Aguero on the edge of the box and he curled the ball into the corner.
Aguero and City's third then arrived, and again it was Silva who created as he tormented Wigan's defence before threading it through for the ubiquitous Argentine to roll home his third.
Aguero sent clean through, takes him time and slots the ball home.
Chelsea maintained their unbeaten start under Andre Villas-Boas with a 2-1 win at Sunderland.
The Black Cats struggles at the Stadium of Light continued as this was their eighth defeat in nine league games at home.
Chelsea captain John Terry opened the scoring just 18-minutes in. Sunderland failed to clear their lines as Juan Mata rattled the woodwork with a free-kick.
The ball then found Terry who blasted the ball across goal, the ball came back for him and from an acute angle he finished with great aplomb.
Chelsea's second arrived just after the break as Raul Meireles's long ball split the home defence to send Daniel Sturridge clear he is closed down but just as he looked set to take it past Simon Mignolet, he back heeled the ball in off the post as Wes Brown failed to clear as he slid in looking to clear it.
Sunderland did give themselves some hope late as on as substitute Ji Dong-won neatly fired home, but Chelsea held on to take the three points back to West London.
Unlike Chelsea, Liverpool bid farewell to their unbeaten start as they lost 1-0 at Stoke City.
The only goal arrived courtesy of the hotly debated penalty as Jamie Carragher hauled down Jonathan Walters in the box. The Irishman dusted himself down and fired home straight past Pepe Reina.
Liverpool pushed for an equaliser for almost the whole of the second-half, but they could not find the net as both Jordan Henderson and Luis Suarez missed great chances to level.
Arsenal bounced back from their mauling at Manchester United with a 1-0 win over Swansea, but it was a thoroughly unconvincing victory for Arsene Wenger's men.
The only goal arrived just before half-time and it was a horrific mistake from goalkeeper Michel Vorm.
The Dutchman prevented the ball going out and looked to start as quick attack and tried to feed Angel Rangel, but he could only hit the Spanish full-back and the ball bounces to the Russian to slot home from an acute angle from the edge of the box.
Swansea pushed late on for an equaliser and in the final seconds Danny Graham fired over from six-yards.
Emmanuel Adebayor maintained his record of scoring on his debut in the Premier League as he helped Tottenham to a 2-0 win at Wolves.
Adebayor had scored on his debuts for previous clubs Arsenal and Man City, and he repeated the feat for Spurs as fellow debutant Scott Parker played him just after the hour, and he rounded Wayne Hennessey to slot home.
The win was confirmed ten-minutes from time as Jermain Defoe exchanged passes with Niko Kranjcar before firing home with Roger Johnson's slip on the edge of the box giving the England striker all the time he needed.
Finally, Aston Villa pegged back Everton twice to claim a 2-2 draw at Goodison Park and maintain their unbeaten record.
Everton opened the scoring midway through the first-half as a great reverse pass from Tim Cahill set-up Leon Osman to slot home.
Villa then, almost from thing, Stiliyan Petrov curled home brilliantly to level just after the hour.
Everton were back in-front not long after as Leighton Baines fired home from the penalty spot as Fabian Delph climbed on Leon Osman.
But Everton were denied the win late on as Gabby Agbonlahor out-jumped Sylvain Distin to head home Marc Albrighton's cross and maintain Villa's unbeaten start to life under Alex McLeish.