Everton's late fightback stunned Manchester United, Chelsea charged on against West Ham and Blackpool triumphed against Newcastle at St James' Park.
Manchester City dropped two points as they were held by Blackburn, while Fulham overcame the loss of Bobby Zamora to defeat Wolves.
Arsenal overcame 10-man Bolton, Tottenham suffered another injury blow in their draw at West Brom and Lee Cattermole saw red again for Sunderland.
Everton produced a stunning recovery with two goals in added time to secure a 3-3 draw against Manchester United at Goodison Park.
The Red Devils, who left Wayne Rooney out of their squad against his former club, looked to be cruising at 3-1 up after goals from Darren Fletcher, Nemanja Vidic and Dimitar Berbatov cancelled out Steven Pienaar's opener.
Tim Cahill headed what looked to be a mere consolation for the Toffees in the first of three added minutes only for Mikel Arteta to lash home a deflected effort just 60 seconds later to send the home fans into raptures.
Chelsea continue to set the pace in the Premier League while West Ham prop up the table with the champions triumphing 3-1 at Upton Park.
The on-form Blues wasted little time in stamping their authority on the struggling Hammers with two goals in the opening 18 minutes, with the hosts complicit in their own downfall.
First, Carlton Cole could only divert Michael Essien's header into his own net, before Rob Green spilled a tame Didier Drogba free-kick and Salomon Kalou cashed in on the rebound.
Essien was on target again in the closing stages with Scott Parker's late response scant consolation for under pressure Avram Grant, although there was still time for Frederic Piquionne to somehow head against the bar from point-blank range.
Blackpool triumphed in the battle of the promoted sides at St James' Park with Charlie Adam and DJ Campbell on the mark to sink Newcastle 2-0.
Adam made no mistake from the spot shortly before the interval after Alan Smith had been penalised for a clear foul on Luke Varney.
And Campbell sent the Magpies fans heading for the exits when he found the back of the net with a neat finish from the edge of the box.
Manchester City's bid to force their way into the Premier League elite suffered another setback as they dropped two home points in a 1-1 draw with local rivals Blackburn.
Joe Hart and Kolo Toure combined to gift Blackburn the opener with neither player taking the opportunity to clear and allowing Nikola Kalinic to roll home into an empty net.
Patrick Vieira levelled for the hosts 10 minutes after the break but despite the best efforts of Carlos Tevez and Jo they could not find a winner.
Fulham striker Zamora suffered a broken ankle in the 2-1 win over Wolves and needed oxygen as he was stretchered from the field.
Jelle Van Damme sneaked in at the far post to fire the visitors ahead in only the 10th minute before Zamora went down in obvious pain after a challenge from Karl Henry on the half hour mark.
But Moussa Dembele bagged a second-half brace - with the winner coming in the closing moments - while Christophe Berra saw red for two bookable offences.
Arsenal made light of their striking shortages with a 4-1 victory over 10-man Bolton at Emirates Stadium.
Laurent Koscielny went from hero to villain for Arsenal as he fired them in front against Bolton before gifting the Trotters possession as Johan Elmander levelled before the break.
Marouane Chamakh had put the Gunners back in front before Gary Cahill was harshly dismissed by referee Stuart Atwell with Alex Song and Carlos Vela punishing the visitors in the closing stages.
Tottenham suffered yet another injury blow as they were forced to settle for a point following their 1-1 draw at West Brom.
Luka Modric fired Tottenham in front in the 27th minute after good work from Rafael van der Vaart and Roman Pavyluchenko, only to be forced off soon after following a number of heavy challenges before heading down the tunnel on crutches.
And the Baggies were level prior to the break as William Gallas was found wanting by Marc-Antoine Fortune, with Chris Brunt nodding home from point-blank range.
Asamoah Gyan repaid the first instalment of his £13million transfer but 10-man Sunderland were forced to settle for a point against Wigan at the DW Stadium.
Lee Cattermole, who insisted prior to the game that he wasn't a dirty player, received his second red card in three Premier League appearances in only the 22nd minute of Sunderland's clash against former club Wigan.
The Black Cats continued to press and Gyan slotted home from close range after Jordan Henderson's sublime cross from the right flank, only for Antolin Alcaraz to cleverly glance home a late equaliser.