Kolo Toure has been ruled out of Arsenal's UEFA Champions League game against Milan on Tuesday evening, but Robin van Persie could return.
With the tie delicately poised following the 0-0 stalemate that ensued two weeks ago in North London, Arsene Wenger would have been desperate to name a full strength XI in Milan.
The influential central defender picked up a calf injury in the first leg and has subsequently missed Arsenal's last two games against Birmingham and Aston Villa; both matches in which they dropped points.
Despite having expressed optimism that he would be fit to make the trip to Italy, it has now been confirmed he will not figure.
Brighter news for Wenger is the return of Robin van Persie following a long-standing problem with his thigh.
The talented Dutchman had been predicted to be one of this season's star players but has been troubled by a succession of injuries.
Following Eduardo's injury the return of Van Persie would provide an ideal tonic between now and the campaign's close.