Arsene Wenger has revealed that four of his stars will not travel to Prague for Wednesday's UEFA Champions League clash against Slavia.
Alexander Hleb, Cesc Fabregas, Kolo Toure and Tomas Rosicky have all remained in North London.
Fabregas and Hleb are to be rested after making 29 starts between them so far this season, while Toure is struggling with a calf problem and Rosicky has an issue with his groin.
"I wanted to take Tomas Rosicky, but he has a slight problem with his groin," Wenger told the club's official website.
"Kolo Toure got a kick on his calf [against Manchester United on Saturday]. He will be okay for Reading on Monday. Rosicky, we don't know yet.
"Alex Hleb and Cesc Fabregas are rested."
The absentees are likely to pave the way for a much rotated starting XI as Wenger looks to keep his stars fresh while securing The Gunners' progression to the knock-out stages.