Spain head coach Vicente del Bosque has named five Liverpool players in his 22-man squad to face England in Seville next week.
Reds goalkeeper Jose Reina, full-back Alvaro Arbeloa, midfielders Albert Riera and Xabi Alonso, and striker Fernando Torres have all been included.
Uncapped Barcelona pair Gerard Pique and Sergio Busquets are surprise inclusions, with the duo impressing for the Primera Divisions giants this season.
Barca captain Carles Puyol has also been included despite recently struggling with a leg injury, but Arsenal skipper Cesc Fabregas is missing due to a long-term knee problem.
Euro 2008 winners Spain, who are unbeaten in their last 28 matches, host Fabio Capello's England on Wednesday 11th February.
Squad in full:
Goalkeepers: Iker Casillas (Real Madrid), Jose Reina (Liverpool).
Defenders: Raul Albiol (Valencia), Alvaro Arbeloa (Liverpool), Joan Capdevila (Villarreal), Juanito (Real Betis),Carlos Marchena (Valencia), Carles Puyol (Barcelona), Sergio Ramos (Real Madrid), Gerard Pique (Barcelona).
Midfielders: David Silva (Valencia), Xabi Alonso (Liverpool), Santi Cazorla (Villarreal), Sergio Busquets (Barcelona), Xavi (Barcelona), Andres Iniesta (Barcelona), Albert Riera (Liverpool), Marcos Senna (Villarreal).
Forwards: David Villa (Valencia), Daniel Guiza (Fenerbahce), Fernando Torres (Liverpool), Fernando Llorente (Athletic Bilbao).