Manchester United's Ben Foster has been ruled out for up to two months.
The England goalkeeper was on the bench for the midweek Champions League clash with Villarreal and finally looked set to push Edwin van der Sar for his number one jersey.
But the injury plagued keeper - who missed most of last season with a cruciate ligament problem, has suffered a fresh setback.
He has now suffered a seriously twisted ankle whilst playing for United's second string against Blackburn - which forced him off after an hour.
"The lad's not getting any luck at all at the moment," United boss Sir Alex Ferguson told Sky Sports News.
"He came down on his ankle in the reserve game last night and he'll be out for six to eight weeks. It's ligament damage.
"He was coming on fantastically well. He was training really well. I made him substitute on Wednesday (against Villarreal) as an indication of his return to fitness.
"He's a top goalkeeper. I just hope he gets a little break now, get over this one and hopefully he won't get anymore unfortunate injuries.
"This is nothing to do with his previous injury of course, where he had a cruciate knee injury, it's just bad luck."