Manchester United's Michael Carrick will miss England's friendly with Czech Republic on Wednesday.
The Red Devils midfielder suffered an ankle injury in United's Premier League opener against Newcastle on Sunday.
The former Tottenham man was forced off after just 25 minutes of the 1-1 draw at Old Trafford.
Speaking to Sky Sports after the game, Sir Alex Ferguson immediately ruled the 27-year-old out of international action.
The United boss claimed Carrick's ankle had "swollen up badly" following his substitution and expects him to be out for "two to three weeks".
Tottenham's Jermaine Jenas has been called up as a replacement.
Jenas was originally left out of Fabio Capello's 23-man party but has been granted a reprieve following Carrick's withdrawal.