Sir Alex Ferguson is looking for top performances from his team when they take on Blackburn in a tricky tie at Ewood Park on Saturday.
Recent history is not on the Red Devils' side as they have lost twice and drawn once in their last four visits to Blackburn.
While United are two points ahead of Chelsea at the top of the table with a game in hand, Ferguson knows his side can not afford to slip up as they to travel to Stamford Bridge for their next league fixture in two weeks' time.
But he has received some leeway after Chelsea dropped two points at home to Wigan on Monday.
Reflecting on the situation, Ferguson said: "This game is hugely significant for us.
"We got the bonus we were looking for when Chelsea dropped two points on Monday and we could not have asked for anything more.
"Ewood Park is not the easiest place to go but we are looking for top performances from our players.
"It is in our hands. We are two points in front with a game in hand, so hopefully we will make it count."
The United boss believes his in-form players need to trust in each other for this difficult game.
He added: "Your players are the ones who have to go out and do it on the pitch.
"They are carrying the burden of pressure.
"Blackburn play attractive, attacking football. They have some exciting players and we have to bear that in mind.
"But the players also need to trust each other because our form is good and we are not searching for anything."
United have been boosted by the return of Nemanja Vidic from a knee injury for the game.
Nani is also ready for a place on the bench after recovering from a thigh injury which kept him out for five games.
But Louis Saha will now miss the rest of the season after being struck down by yet another hamstring injury - just as he was about to make his latest return.
"The season is running out, that is the problem, so this is not good news," Ferguson added.
"Louis has been training really well and was pencilled in to play part of the game at Blackburn."