Plymouth Argyle ruined Paul Sturrock's return to Home Park by inflicting a 3-1 defeat on his current charges Southampton.
The Pilgrims dominated the opening period and went ahead after 16 minutes when Micky Evans headed home.
Bobby Williamson's men doubled their advantage ten minutes before the interval when Graham Coughlan scored and new signing Steven Milne made it 3-0 just moments into the second period.
James Beattie pulled one back with a 25-yard free kick, but The Saints could not prevent their first loss of pre-season.
Tottenham Hotspur sealed a 2-0 victory over Nottingham Forest at The City Ground.
The opener came on 38 minutes when Fredi Kanoute linked up with Jermain Defoe on the edge of the area before slotting home.
Defoe grabbed the second on the hour mark when he slammed home a penalty after French trialist Dagui Bakari was fouled by Jon-Olav Hjelde.
Steve Bruce's Birmingham City grabbed a comfortable 4-1 victory at The KC Stadium over Hull City.
Clinton Morrison opened the scoring after 14 minutes and Muzzy Izzet doubled their lead before half time with a low drive.
A Damien Delaney own goal added another before Robbie Savage made it four from the penalty spot on 54 minutes.
Hull substitute Stuart Green added a late consolation for the home side.
Norwich City continued their pre-season preparations with a 0-0 draw at Coventry City.
Fulham grabbed victory in Scotland with a 2-0 win over Hearts.
Zat Knight headed home the winner after just five minutes, while Andy Cole opened his Fulham account with the second late in the game.
Big spending Middlesbrough went down to their first defeat in pre-season as they lost 3-1 to Bundesliga outfit Hansa Rostock.
Boro travelled to Germany to celebrate the 50th anniversary of Hansa's Ostseestadion, but they could not continue their recent winning ways.
A full strength Boro - who included Dutch duo Michael Reiziger and Boudewijn Zenden for the first time this summer - went behind just seven minutes into the second period when Kim Madsen struck.
Rene Rydlewicz then slotted home from the penalty spot to make it 2-0.
Substitute Joseph-Desire Job pulled one back for Steve McClaren's side, but Hansa added another in the final minute through Thomas Meggle to seal victory.
One worrying issue for Boro is that Reiziger was forced off in the first half with a shoulder injury.
Bolton Wanderers were held to a 2-2 draw by Sheffield Wednesday at Hillsborough.
The Trotters went ahead after 39 minutes when Kevin Davies headed home Ricky Shakes's cross, but The Owls levelled just before the interval with new boy Steven MacLean slotting home from the spot.
MacLean then doubled his tally just moments into the second period when he headed home Lee Peacock's cross.
Bolton managed to get back on level terms when highly rated youngster James Sinclair rifled home from the edge of the area.
Blackburn Rovers sealed a 1-0 friendly victory over locals rivals Preston North End at Deepdale.
The only goal of the game came after 20 minutes when new signing Paul Dickov finished from close range after Jon Stead saw his effort blocked.
Crystal Palace suffered a poor 3-0 reversal at Championship outfit Queens Park Rangers.
Goals either side of half time from Tony Thorpe and Paul Furlong put The R's 2-0 up. Kevin Gallen completed the scoring five minutes from time.
Charlton Athletic were held to a 1-1 draw by Luton Town at Kenilworth Road.
Graham Stuart headed his side in front after 54 minutes following good work from young defender Osei Sankofa.
The League One side struck back however and Stephen O'Leary reacted quickly to fire home after Dean Kiely had blocked Enoch Showunmi's effort.
West Bromwich Albion suffered a 2-1 reversal at the hands of Stoke City at The Britannia Stadium.
Midfielder Dave Brammer opened the scoring with a brilliant 35-yard effort which was soon followed by a close range effort from Ade Akinbiyi.
Scott Dobie pulled one back just before the interval for West Brom, but The Baggies could not find an equaliser.
A largely inexperienced Portsmouth side played out a 0-0 draw with Aldershot Town at The Recreation Ground.
Likewise a young Aston Villa side secured a 3-0 win at non-league Tamworth.
Manchester City's reserves came away from Leigh RMI with a 5-0 victory.
Finally, a Manchester United XI secured a 3-1 win over Corinthian Casuals with Sylvan Ebanks Blake, Ramon Calliste and Colin Heath scoring.
