Round 40 of Super 6 takes in the four Saturday 3pm kick-offs in the Premier League plus two Sky Bet Championship clashes.
As ever, your Soccer Saturday host Jeff Stelling is on hand to provide his predictions and information to help you along your way.
Enter the free-to-play football predictor game before 3pm on Saturday for your chance of landing the £250,000 jackpot, while at least £5,000 is up for grabs for the week's most accurate entry if no one claims the grand prize.
Aston Villa v Southampton
Opta Stat: Aston Villa have lost four Premier League games in a row, their worst run since 2001.
Jeff says: "Villa are in turmoil internally and have already suffered a club record 10 home defeats in the Premier League this season."
Jeff predicts: Aston Villa 0 Southampton 2
Most likely scoreline according to Sky Bet's odds: Aston Villa 1 Southampton 1 - 5/1
Cardiff v Stoke
Opta Stat: Cardiff are without a win in seven against the Potters in all competitions, drawing three and losing four.
Jeff says: "Cardiff have conceded 12 in last four home games and they're likely to leave the backdoor open again in their desperate search for a win."
Jeff predicts: Cardiff 1 Stoke 2
Most likely score according to Sky Bet's odds: Cardiff 1 Stoke 1 - 5/1
Newcastle v Swansea
Opta Stat: The Magpies have lost six of their last eight home league games, failing to score in all six defeats (W2).
Jeff says: "Newcastle must score again soon but that may not be enough."
Jeff predicts: Newcastle 1 Swansea 2
Most likely scoreline according to Sky Bet's odds: Newcastle 1 Swansea 1 - 5/1
West Ham v Crystal Palace
Opta Stat: Crystal Palace have won just five of their 24 away London derbies in the Barclays Premier League (D5 L14).
Jeff says: "Palace have only ever won here once before and I expect that record to remain."
Jeff predicts: West Ham 2 Crystal Palace 0
Most likely scoreline according to Sky Bet's odds: West Ham 1 Crystal Palace 1 - 5/1
Barnsley v Leeds
Stat: Leeds ended a five-match losing streak with last weekend's 2-0 win over Blackpool.
Jeff says: "Leeds have lost their last four Yorkshire derbies here, conceding 14 times."
Jeff predicts: Barnsley 1 Leeds 0
Most likely score according to Sky Bet's odds: Barnsley 1 Leeds 1 - 5/1
Watford v Ipswich
Stat: Watford have scored in each of their last nine games, including two or more times in six of those games.
Jeff says: "Free-scoring Watford have too much firepower for the Tractor Boys."
Jeff predicts: Watford 2 Ipswich 1
Most likely score according to Sky Bet's odds: Watford 1 Ipswich 1 - 5/1