With Super Sunday's fixtures in mind, your Sky Sports Fantasy Football team could suffer if it's largely made up of players from Liverpool, Everton, Manchester United and Chelsea this weekend.
The quartet will certainly be taking points off each other, with Sky Bet going odds-on that both teams score in each meeting, while the Merseyside derby is to be stayed clear of having produced considerably more red cards than any other fixture in the Premier League era.
Stop short of giving your team a complete overhaul on the basis of one weekend, though, but eye up your chosen XI and identify the players most likely to be vulnerable at Anfield and indeed Old Trafford.
Arsenal right-back Bacary Sagna struggled to cope with United's attack from the left during their 1-1 draw last weekend, and Chelsea's full-back Cesar Azpilicueta could suffer a similar afternoon on Sunday.
The Blues are only 100/30 to keep a clean sheet on United's turf, so at £5.5m Azpilicueta, who has received six yellow cards in just 21 starts, could be shipped out and replaced with perhaps John O'Shea (Sunderland) or Emerson Boyce (Wigan) at the same price.
O'Shea is probably the wiser choice as the Black Cats host a Stoke side who have failed to score on their last four visits to the Stadium of Light, while the two sides played out a 0-0 draw at the Britannia Stadium earlier this season. Thus, it's definitely a game you want to have some defenders involved in.
Alternatively, Wigan's Boyce may prove a shrewd buy at £5.5m having scored his third goal of the season against Tottenham last week. The 33-year-old defender is always a threat from set-pieces, and the Latics have scored 26% of their goals from corners this season, a divisional high.
Elsewhere, Manchester City's league form, albeit too-little-too-late, should be exploited, with Sergio Aguero a must for any side in need of a top-class striker. The Argentine is reasonably priced at £9.9m, with three goals in his last five outings in all competitions.
If you're after an injection of life into your midfield without breaking the bank, Samir Nasri has hit form in the latter stages of the season and is available to slot into your side for just £7.6m, while goalkeeper Joe Hart (£6m) has kept more clean sheets than any other (15), regardless of his blunder against West Ham last time out.
The England goalkeeper's comical error prompted a flurry of Fantasy Managers to drop him as their number one, but that's a decision there to be trumped by competitors as City should have more than enough to beat struggling Swansea to nil (21/10) on Saturday.