Barclays Premier League champions Chelsea begin the defence of their title with a home match against newly promoted West Brom.
The August 14 clash sees a return to Stamford Bridge for former Blues midfielder Roberto Di Matteo, now manager of Albion.
Next up for the champions will be a trip to Wigan, where they were beaten last season, before Stoke visit Stamford Bridge on August 28.
The title holders have to wait until October 2 for their first match against one of the big four clubs, when they face Arsenal at home, with the return fixture on Boxing Day.
Carlo Ancelotti's side first play Manchester United on December 18, with the two shaping up at Old Trafford on May 7 - the Blues' penultimate away fixture.
United, runners-up in 2009-10, also start with a home match against a newly-promoted team. Sir Alex Ferguson's side take on Newcastle on the first day.
And Blackpool, the third of the sides promoted from the Championship, provide the Old Trafford opposition on the last day of the season, May 22.
There are two intriguing matches between top-four hopefuls on the opening day. Liverpool start the post-Rafa Benitez era with a home match against Arsenal, while Tottenham and Manchester City meet at White Hart Lane.
Aston Villa face West Ham and Everton travel to Blackburn, while Blackpool's first match in the Premier League is at home, to local rivals Wigan.
Elsewhere on the opening day, Steve Bruce's Sunderland are at home to Birmingham, one of the clubs he previously managed.
Wolves and Stoke clash at Molineux, while Bolton and Europa League runners-up Fulham meet in the North West.
Now the fixtures have been announced, the process of selecting games for live TV coverage begins.
This season Sky Sports will show 115 live matches from the Barclays Premier League. We expect to announce the first batch of live matches in a couple of weeks followed by initial selections from the Football League and the Scottish Premier League.
As soon as any live television fixtures are confirmed they will be announced on Sky Sports News and on skysports.com.
Sky Bet have released their prices for the opening day's Premier League games and make Newcastle 12/1 shots to beat Manchester United (2/9) and Chelsea (1/7) to beat West Brom (14/1). Click here to see all Premier League markets.
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