Mikael Silvestre and Eduardo have been ruled out of Arsenal's Premier League clash with Portsmouth on Saturday and could miss Tuesday's tie with Manchester United.
Manager Arsene Wenger confirmed the Gunners will be without both defender Silvestre and forward Eduardo for the trip to Fratton Park with groin injuries.
The pair both picked up problems in Wednesday's 1-0 defeat to United in the semi-finals of the UEFA Champions League and could be doubts for the return leg at the Emirates next week.
"For the weekend we have lost Eduardo certainly," Wenger confirmed.
"He has done his groin again unfortunately. Rio Ferdinand fell on him when he had that accident. His knee went on his groin and that detached some fibres. Silvestre has a groin (injury) as well.
"We have not scanned them yet, so we don't know about Tuesday, but they both miss Saturday for sure."