Arsene Wenger will be looking to captain Robin van Persie to ensure Arsenal produce a statement of intent when Swansea visit the Emirates this weekend.
After two weeks of stewing on the humiliation of an 8-2 thumping by Manchester United, the Gunners have the perfect opportunity to bounce back against a side yet to net since arriving in the Premier League.
While Wenger's men have just a single point to their name this season, Van Persie (£9.5m) has netted for his side in their last two games, in the Champions League and then at Old Trafford, and can be expected to continue to rack up the points against the Swans.
Much will also be expected from transfer deadline day signing Mikel Arteta, after Wenger strayed away from his normal transfer policy to land the experienced playmaker for £10m.
Arteta is likely to share the set-piece responsibilities with Van Persie and is one of the Gunners' cheapest players as he carries a £5.1m valuation over from Everton.
Per Mertesacker (£6.9m), Andre Santos (£5.4m) and Yossi Benayoun (£4.7m) will also be looking to make an impression after arriving on deadline day, and could go straight in to Wenger's starting line-up with Thomas Vermaelen (foot), Carl Jenkinson (suspended) and Jack Wilshere (ankle) all sidelined.
While the Gunners will be looking to bounce back, Manchester City will simply be aiming to maintain momentum, having scored 12 goals in their opening three wins, when Wigan come to visit.
Edin Dzeko (£8m) was the chief executioner in City's 5-1 thumping of Tottenham, bagging four goals and Sky Sports' man of the match award to rack up 27 points, and is now the game's leading scorer with 41 points.
David Silva (£8.4m) and Sergio Aguero (£9.6m) have also been racking up the points - 26 and 23 respectively - this term in a City side that, ominously for visitors to the Etihad Stadium, seem to have broken free of the shackles of old.
After City did their keeping up with the Jones' act in destroying Tottenham, neighbours Manchester United went and built the equivalent of an extension made out of platinum with their 8-2 win at Old Trafford.
Wayne Rooney (£9.9m) and Ashley Young (£7.9m) were the key instigators and picked up 25 and 20 point respectively, with the former bagging a hat-trick and the latter bagging a brace and three assists.
After both netting for England in their Euro 2012 qualifiers during the international break, it would take a brave Fantasy boss to write off the pair from continuing to score big when United visit Bolton on Saturday evening.
Owen Coyle has the added concern of the returning Javier Hernandez, who has a point to prove after seeing Danny Welbeck, now sidelined for a month with a hamstring injury, impress during his head-injury enforced absence.
The Mexico striker scored 13 goals from just 15 starts to pile up 103 points last season and boasts the best goal-per-minute ratio in the Premier League's history.
Sir Alex's youthful side will, however, need to be wary of the threat of Ivan Klasnic, who is proving one of the bargain buys of the season at £5.6m, having racked up 23 points with a goal in all three of the Trotters' games to date.
At just £0.5m more, Emmanuel Adebayor has the potential to be another shrewd signing after completing his season-long loan move to Tottenham, where he looks likely to be the first-choice frontman.
Having terrorised the Tottenham backline so many times while at Arsenal and then Real Madrid, Harry Redknapp will be hoping the powerful striker can do the same for Spurs as he did against them.
The Togo frontman should have plenty of good service for his debut at Wolves with Gareth Bale (£7.7m) looking sharp and Luka Modric (£6.3m) still around, although Rafael van der Vaart will miss the next six weeks with a hamstring injury.
However, Spurs face a stiff task in breaching a backline which has only conceded once this term, with Stephen Ward (£4.3m) and Roger Johnson (£4.8m) the game's two highest scoring defenders so far with 20 and 22 points respectively.
One man who has already made his debut and celebrated it with a goal was Juan Mata (£7.8m), and he will be looking to cement a starting place when Chelsea visit Sunderland.
Jose Bosingwa (£6.5m), a cheaper option than many of his team-mates, also bagged against Norwich a fortnight back to take his points tally up to a club-high of 16, while the man employed to net but is yet to do so Fernando Torres (£9.4m) continues to disappoint.
Elsewhere, Liverpool travel to a Stoke side with buoyed by the acquisitions of Wilson Palacios (£4.7m), Peter Crouch (£7.5m) and Cameron Jerome (£5.5m).
Both sides head in to the clash unbeaten and Kenny Dalglish will be looking to impressive performers Luis Suarez (£8.8m) and Charlie Adam (£5.9m) to ensure it is his side that leave the Britannia with that record intact, while Andy Carroll (£9.3m) has a point to prove after England boss Fabio Capello questioned his fitness.